| Health and Mental Hygiene Commissioner | Dr. Alister Martin | Emergency room physician at Massachusetts General Hospital | Oversee public health, manage disease outbreaks and expand access to affordable care. |
| Correction Commissioner | Stanley Richards | Executive vice president of the Fortune Society | Improve safety, close Rikers Island and support people in custody and staff. |
| Veterans’ Services Commissioner | Yesenia Mata | Executive director of La Colmena | Connect veterans to housing, health care, entrepreneurship and support services. |
| Youth and Community Development Commissioner | Sandra Escamilla-Davies | Executive vice president of Children’s Aid | Strengthen after-school, youth employment and homeless youth programs. |
| Administrative Trials and Hearings Commissioner | Vilda Vera Mayuga | Commissioner of the Department of Consumer and Worker Protection | Ensure fair and transparent administration of justice at OATH. |
| Probation Commissioner | Sharun Goodwin | Probation officer trainee | Expand engagement and opportunity for people on probation. |
| Citywide Administrative Services Commissioner | Yume Kitasei | Chief of staff to the first deputy mayor | Oversee workforce, assets, properties and procurement. |
| Environmental Protection Commissioner | Lisa Garcia | EPA regional administrator for Region 2 | Protect infrastructure, water systems and advance climate resilience. |
| Transportation Commissioner | Mike Flynn | Director of capital planning and project initiation | Advance safer streets, faster buses and affordability. |
| Housing Preservation and Development Commissioner | Dina Levy | Senior vice president of homeownership and community development | Execute the administration’s affordable housing agenda. |
| Media and Entertainment Commissioner | Rafael Espinal | Executive director of the Freelancers Union | Support artists and creative workers citywide. |
| Mass Engagement Commissioner | Tascha Van Auken | Campaign manager for state Sen. Julia Salazar | Lead citywide mass engagement and civic participation efforts. |
| Schools Chancellor | Kamar Samuels | Principal | Expand high-quality 3-K and pre-K programs. |
| Consumer and Worker Protection Commissioner | Sam Levine | Director of the FTC Bureau of Consumer Protection | Lead crackdown on junk fees. |
| Police Commissioner | Jessica Tisch | — | Advance precision policing strategy. |
| Labor Relations Commissioner | Renee Campion | First deputy commissioner | Manage labor contract negotiations and enforcement. |